Nolvadex also called tamoxifen is a non-steroidal anti-estrogen that competitively inhibits estrogen receptors in the target organs and tumors therein. The mechanism of action has not been fully investigated, although it is known that a complex of Nolvadex with the receptor and cofactor appears and is then transferred to the cell nucleus, preventing hypertrophy of the cells dependent on regulation by estrogen. The effect of the medication can last for several weeks after a single dose. Nolvadex can induce ovulation in women, stimulate the production of gonadotropic hormones of pituitary gland. In men with oligospermia, it increases the concentration of luteinizing hormone and follicle-stimulating hormone, testosterone and estrogen in the blood serum. Nolvadex is used to treat breast cancer in women and men (especially after castration) and also when it has spread to other parts of the body, kidney cancer, melanoma and sarcomas of the soft tissues with estrogen receptors, cancer of the ovary. Wikipedia

Dosage and direction of tamoxifen

Take it exactly as recommended by your doctor as the dosage depends on your condition. Long treatment (about 2 years) is advised. Take this medication with food and a large glass of water as a single dose or divide it in half (taken morning and evening), do not chew or crush.

Precautionary actions

This drug may increase the chance of developing endometrial cancer. Patients treated with Nolvadex should be monitored for abnormal vaginal bleeding, changes in menstrual periods, changes in vaginal discharge, or pelvic pain or pressure.

Contraindications

Nolvadex is contraindicated in patients with hypersensitivity to this drug and also in women threatened by coumarin-type anticoagulants or in women with deep vein thrombosis or pulmonary embolism in history, pregnant or lactating women. Caution is advised in patients with eye diseases (including cataracts), hyperlipidemia, leukopenia, thrombocytopenia, hypercalcemia, severe thrombophlebitis, thromboembolism (also in history).

Tamoxifen side effects

Side effects are not expected. If they change from mild to severe, report this to your doctor immediately. Side effects caused by Nolvadex include: hot flashes, nausea, vomiting, weight gain, abnormal menstruation.

Drug interaction

Nolvadex can cause abnormalities in liver and blood tests, so regular monitoring of side effects caused by Nolvadex is required. If symptoms such as jaundice and bleeding occur, the patient should immediately seek medical attention.

Missed dose

If you forget to take your dose on time, do so as soon as you remember. But don’t take it if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usual dose at the same regular time the next day.